曾國藩 教授 Tseng, Guo-Fang Professor
最高學歷:University of Wisconsin-Madison博士
研究專長:神經傷害與神經再生研究
聯絡方式:038565301轉7162/ 2144
[email protected]
研究室/實驗室:F320/ F321-1
- Office/ Laboratory Site: F320-1
- Tel.: (03)3565301-7162
- Research Interests: In general, the lab focused on 3 areas of interests.
(2) The plasticity of cerebral cortex under normal aging. The effect of sex hormones, in particular, on cortical neuronal dendritic spines are scrutinized.
(3) The efficacy of different approaches of the neurorrhaphy of peripheral nerves following injury as well as investigation on the means to facilitate the recovery.
學歷
1983~1988 University of Wisconsin-Madison 博士
1977~1980 國立台灣大學醫學院解剖學研究所 碩士
1972~1977 國立台灣師範大學生物系 學士
1977~1980 國立台灣大學醫學院解剖學研究所 碩士
1972~1977 國立台灣師範大學生物系 學士
現職
- Vice president,
- Dean, Research and Development, Director, Medical Simulation Center,
- Professor of Anatomy Tzu Chi University
2006~迄今 慈濟大學 醫學院 解剖學科 教授兼研發長、模擬醫學中心主任
2006~迄今 國立台灣大學 醫學院 解剖學科暨細胞生物學科(研究所) 兼任教授
2006~迄今中華民國解剖學會理事長
- Dean, Research and Development, Director, Medical Simulation Center,
- Professor of Anatomy Tzu Chi University
2006~迄今 慈濟大學 醫學院 解剖學科 教授兼研發長、模擬醫學中心主任
2006~迄今 國立台灣大學 醫學院 解剖學科暨細胞生物學科(研究所) 兼任教授
2006~迄今中華民國解剖學會理事長
經歷
2003~2006 北區六所醫學院校遺體分配中心 主任
2003~2006 國立台灣大學 醫學院 解剖學科(研究所) 教授兼主任(所長)
1998~2006 慈濟大學 醫學院 解剖學科 特聘教授
1998~2003 國立台灣大學 醫學院 解剖學暨細胞生物學科(研究所) 教授
1991~1997 國立台灣大學 醫學院 解剖學科暨細胞生物學科(研究所) 副教授
1988~1991 Stanford University, Neurology 博士後研究員
考選部典試委員
中華民國解剖學會 理事
社團法人台北市野鳥學會 理事長 (2001-2005)
社團法人台北市野鳥學會 常務理事,理事
台北鳥會 會長 (1982-1983)
台北鳥會 理事
2003~2006 國立台灣大學 醫學院 解剖學科(研究所) 教授兼主任(所長)
1998~2006 慈濟大學 醫學院 解剖學科 特聘教授
1998~2003 國立台灣大學 醫學院 解剖學暨細胞生物學科(研究所) 教授
1991~1997 國立台灣大學 醫學院 解剖學科暨細胞生物學科(研究所) 副教授
1988~1991 Stanford University, Neurology 博士後研究員
考選部典試委員
中華民國解剖學會 理事
社團法人台北市野鳥學會 理事長 (2001-2005)
社團法人台北市野鳥學會 常務理事,理事
台北鳥會 會長 (1982-1983)
台北鳥會 理事
榮譽
國立台灣大學 84學年度 優良教學獎
國立台灣大學醫學院(1996年) 基礎醫學 最佳教師獎
國立台灣大學醫學院85學年度 醫學系 教學獎
國立台灣大學醫學院87學年度 教學傑出獎
國立台灣大學87學年度 教學傑出獎 (五年內免議)
國立台灣大學93學年度 教學優良獎
國立台灣大學94學年度 教學優良獎
社團法人台北市野鳥學會 常務理事,理事
台北鳥會 會長 (1982-1983)
台北鳥會 理事
國立台灣大學醫學院(1996年) 基礎醫學 最佳教師獎
國立台灣大學醫學院85學年度 醫學系 教學獎
國立台灣大學醫學院87學年度 教學傑出獎
國立台灣大學87學年度 教學傑出獎 (五年內免議)
國立台灣大學93學年度 教學優良獎
國立台灣大學94學年度 教學優良獎
社團法人台北市野鳥學會 常務理事,理事
台北鳥會 會長 (1982-1983)
台北鳥會 理事
學術期刊成果
16. Chen, LJ, Chen, JR, Tseng, GF (2022) Modulation of striatal glutamatergic, dopaminergic and cholinergic neurotransmission pathways concomitant with motor disturbance in rats with kaolin-induced hydrocephalus. Fluids and Barriers of the CNS (Accepted and in press)
15. Chen, LJ, Tsai, ST, Tseng, GF (2022) Rodent models of senile normal pressure hydrocephalus. Tzu Chi Medical Journal (in press)
14.Chen, LJ, Wang, YJ, Tseng, GF (2017) Cortical compression rapidly trimmed transcallosal projections and altered axonal anterograde transport machinery. Neuroscience 362:79-94
13.Chen, LJ, Wang, YJ, Chen, JR, Tseng, GF (2016) Hydrocephalus compacted cortex and hippocampus and altered their output neurons in association with
spatial learning and memory deficits in rats. Brain pathology 27:419-436
12. Tsai ST; Chen LJ; Wang YJ; Chen SY; Tseng GF. (2016) Rostral Intralaminar Thalamic Deep Brain Stimulation Triggered Cortical and Hippocampal Structural
Plasticity and Enhanced Spatial Memory. Stereotact Funct Neurosurg 94:108-117
11. Li-jin Chen, Ph.D.; Yueh-Jan Wang, Ph.D.; Jeng-Rung Chen, Ph.D.; Guo-Fang Tseng, Ph.D. (2015) NMDA receptor triggered molecular cascade underlies
compression-induced rapid dendritic spine plasticity in cortical neurons. Experimental neurology. 266:86-98
10. Lim SH, Wang TJ, Tseng GF, Lee YF, Huang YS, Chen JR, Cheng CL (2013) The Distribution of Muscles Fibers and Their Types in the Female Rat Urethra: Cytoarchitecture and Three-Dimensional Reconstruction. Anat Rec (Hoboken)
9. Chen JR, Wang TJ, Lim SH, Wang YJ, Tseng GF (2013). Testosterone modulation of dendritic spines of somatosensory cortical pyramidal neurons.
Brain Struct Funct.
8. Huang SH, Wang YJ, Tseng GF, Ho HC (2012) Active endocytosis and microtubule remodeling restore compressed pyramidal neuron morphology in rat
cerebral cortex. Cell Mol Neurobiol 32: 1079-1087.
7. Liao WC, Chen JR, Wang YJ, Tseng GF (2010) Methylcobalamin, but not methylprednisolone or pleiotrophin, accelerates the recovery of rat biceps after
ulnar to musculocutaneous nerve transfer. Neuroscience 171: 934-949.
6. Chen LJ, Wang YJ, Tseng GF (2010) Compression alters kinase and phosphatase activity and tau and MAP2 phosphorylation transiently while inducing the
fast adaptive dendritic remodeling of underlying cortical neurons. J Neurotrauma 27: 1657-1669.
5. Chen JR, Wang TJ, Wang YJ, Tseng GF (2010) The immediate large-scale dendritic plasticity of cortical pyramidal neurons subjected to acute epidural
compression. Neuroscience 167: 414-427.
4. Liao WC, Chen JR, Wang YJ, Tseng GF (2009) The efficacy of end-to-end and end-to-side nerve repair (neurorrhaphy) in the rat brachial plexus. J Anat
215: 506-521.
3. Chen JR, Wang TJ, Huang HY, Chen LJ, Huang YS, Wang YJ, Tseng GF (2009) Fatigue reversibly reduced cortical and hippocampal dendritic spines
concurrent with compromise of motor endurance and spatial memory. Neuroscience 161: 1104-1113.
2. Chen JR, Yan YT, Wang TJ, Chen LJ, Wang YJ, Tseng GF (2009) Gonadal hormones modulate the dendritic spine densities of primary cortical pyramidal
neurons in adult female rat. Cereb Cortex 19: 2719-2727.
1. Wang TJ, Chen JR, Wang YJ, Tseng GF (2009) The cytoarchitecture and soma-dendritic arbors of the pyramidal neurons of aged rat sensorimotor cortex: an
intracellular dye injection study. Neuroscience 158: 776-785.
15. Chen, LJ, Tsai, ST, Tseng, GF (2022) Rodent models of senile normal pressure hydrocephalus. Tzu Chi Medical Journal (in press)
14.Chen, LJ, Wang, YJ, Tseng, GF (2017) Cortical compression rapidly trimmed transcallosal projections and altered axonal anterograde transport machinery. Neuroscience 362:79-94
13.Chen, LJ, Wang, YJ, Chen, JR, Tseng, GF (2016) Hydrocephalus compacted cortex and hippocampus and altered their output neurons in association with
spatial learning and memory deficits in rats. Brain pathology 27:419-436
12. Tsai ST; Chen LJ; Wang YJ; Chen SY; Tseng GF. (2016) Rostral Intralaminar Thalamic Deep Brain Stimulation Triggered Cortical and Hippocampal Structural
Plasticity and Enhanced Spatial Memory. Stereotact Funct Neurosurg 94:108-117
11. Li-jin Chen, Ph.D.; Yueh-Jan Wang, Ph.D.; Jeng-Rung Chen, Ph.D.; Guo-Fang Tseng, Ph.D. (2015) NMDA receptor triggered molecular cascade underlies
compression-induced rapid dendritic spine plasticity in cortical neurons. Experimental neurology. 266:86-98
10. Lim SH, Wang TJ, Tseng GF, Lee YF, Huang YS, Chen JR, Cheng CL (2013) The Distribution of Muscles Fibers and Their Types in the Female Rat Urethra: Cytoarchitecture and Three-Dimensional Reconstruction. Anat Rec (Hoboken)
9. Chen JR, Wang TJ, Lim SH, Wang YJ, Tseng GF (2013). Testosterone modulation of dendritic spines of somatosensory cortical pyramidal neurons.
Brain Struct Funct.
8. Huang SH, Wang YJ, Tseng GF, Ho HC (2012) Active endocytosis and microtubule remodeling restore compressed pyramidal neuron morphology in rat
cerebral cortex. Cell Mol Neurobiol 32: 1079-1087.
7. Liao WC, Chen JR, Wang YJ, Tseng GF (2010) Methylcobalamin, but not methylprednisolone or pleiotrophin, accelerates the recovery of rat biceps after
ulnar to musculocutaneous nerve transfer. Neuroscience 171: 934-949.
6. Chen LJ, Wang YJ, Tseng GF (2010) Compression alters kinase and phosphatase activity and tau and MAP2 phosphorylation transiently while inducing the
fast adaptive dendritic remodeling of underlying cortical neurons. J Neurotrauma 27: 1657-1669.
5. Chen JR, Wang TJ, Wang YJ, Tseng GF (2010) The immediate large-scale dendritic plasticity of cortical pyramidal neurons subjected to acute epidural
compression. Neuroscience 167: 414-427.
4. Liao WC, Chen JR, Wang YJ, Tseng GF (2009) The efficacy of end-to-end and end-to-side nerve repair (neurorrhaphy) in the rat brachial plexus. J Anat
215: 506-521.
3. Chen JR, Wang TJ, Huang HY, Chen LJ, Huang YS, Wang YJ, Tseng GF (2009) Fatigue reversibly reduced cortical and hippocampal dendritic spines
concurrent with compromise of motor endurance and spatial memory. Neuroscience 161: 1104-1113.
2. Chen JR, Yan YT, Wang TJ, Chen LJ, Wang YJ, Tseng GF (2009) Gonadal hormones modulate the dendritic spine densities of primary cortical pyramidal
neurons in adult female rat. Cereb Cortex 19: 2719-2727.
1. Wang TJ, Chen JR, Wang YJ, Tseng GF (2009) The cytoarchitecture and soma-dendritic arbors of the pyramidal neurons of aged rat sensorimotor cortex: an
intracellular dye injection study. Neuroscience 158: 776-785.
研討會論文
16. Li-Jin Chen, Hsiao-Wen Lai, Yueh-Jan Wang, Guo-Fang Tseng (2019, Mar). Intracerebroventricular streptozotocin injection reduced CA1 pyramidal neuronal dendritic spines and impaired cognitive function in rats. 2019 International Anatomical Sciences and Cell Biology,
15. Li-Jin Chen, Chin-Wen Chiang, Ling -Chia Wang, Yueh-Jan Wang, Guo-Fang Tseng (2019, Mar).The effects of surgical menopause on striatal medium spiny neurons. 2019 International Anatomical Sciences and Cell Biology,
14. Guo-Fang Tseng (2018, Mar).Silent mentor case study: extending the benefits of willed body program. 2018 International Anatomical Sciences and Cell Biology,
13. Li-Jin Chen, Ti-Yin Cheng, Yueh-Jan Wang, Guo-Fang Tseng (2018, Mar).The effects of infantile hydrocephalus on the striatum of the basal ganglia in a kaolin-induced rat model. 2018 International Anatomical Sciences and Cell Biology,
12. Li-Jin Chen, Hsiao-Wen Lai, Yueh-Jan Wang, Guo-Fang Tseng (2017, Mar). Intraventricular streptozotocin injection impaired cognition and reduced excitatory drives to the hippocampus in rats. 2017 International Anatomical Sciences and Cell Biology,
11. Li-Jin Chen, Ti-Yin Cheng, Yueh-Jan Wang, Guo-Fang Tseng (2017, Mar). The effects of experimental childhood hydrocephalus on the striatum in a rat model. 2017 International Anatomical Sciences and Cell Biology,
10. Li-Jin Chen, Ling-Chia Wang, Yueh-Jan Wang, Guo-Fang Tseng (2017, Mar). Focal cerebral compression results in irreversible contralateral cortical changes. 2017 International Anatomical Sciences and Cell Biology,
9. Guo-Fang Tseng, Li-Jin Chen, Yueh-Jan Wang (2016, Jul). Alteratios of the cerebral cortex and hippocampus in kaolin-induced hydrocephalic rats: a
stereological and intracellular dye injection study.
8. Li-Jin Chen, Ling-Chia Wang, Yueh-Jan Wang, Guo-Fang Tseng (2016, Mar).Unilateral cerebral compression affects contralateral cortex via downregulation of commissural projection profuseness and axonal transport machinery. 2015 International Anatomical Sciences and Cell Biology,
7. Li-Jin Chen, Ling-Chia Wang, Yueh-Jan Wang, Guo-Fang Tseng (2016, Mar).The Effects of Surgical Menopause Estrogen Receptor Expression and Dendritic
Spines in the Motor cortex. 2015 International Anatomical Sciences and Cell Biology,
6. Li-Jin Chen, Ling-Chia Wang, Yueh-Jan Wang, Guo-Fang Tseng (2016, Mar).Alteration of striatal glutamate and dopamine receptors accompanied motor
impairment in hydrocephalus. 2015 International Anatomical Sciences and Cell Biology,
5. Li-Jin Chen, Jeng-Rung Chen, Siang-Ying Huang, Yueh-Jan Wang, Guo-Fang Tseng (2014, Dec). The effect of chronic hydrocephalus and shunt treatment on
cortex and hippocampus in rats. 2014 International Anatomical Sciences and Cell Biology.
4. Li-Jin Chen, Ling-Chia Wang, Yeh-Yu Hsuan, Yueh-Jan Wang, Guo-Fang Tseng (2014, Dec). The effects of compression and decompression on the callosal
transmission of sensorimotor cortex. 2014 International Anatomical Sciences and Cell Biology.
3. Li-Jin Chen, Jeng-Rung Chen, Siang-Ying Huang, Yueh-Jan Wang, Guo-Fang Tseng (2014, Mar). Hydrocephalus and shunt treatment: effects on cortex and
hippocampus. 2014 Joint Annual Conference of Biomedical Science.
2. Li-Jin Chen, Jeng-Rung Chen, Siang-Ying Huang, Yueh-Jan Wang, Guo-Fang Tseng (2013, Mar). A stereological and cellular analysis on the effects of
hydrocephalus on cerebral cortex and hippocampus. 2013 Joint Annual Conference of Biomedical Science.
1. Li-Jin Chen, Ling-Chia Wang, Yueh-Jan Wang, Guo-Fang Tseng (2013, Mar). Compression reduces the transcortical projection of underlying cortex. 2013
Joint Annual Conference of Biomedical Science.
16. Li-Jin Chen, Hsiao-Wen Lai, Yueh-Jan Wang, Guo-Fang Tseng (2019, Mar). Intracerebroventricular streptozotocin injection reduced CA1 pyramidal neuronal dendritic spines and impaired cognitive function in rats. 2019 International Anatomical Sciences and Cell Biology,
15. Li-Jin Chen, Chin-Wen Chiang, Ling -Chia Wang, Yueh-Jan Wang, Guo-Fang Tseng (2019, Mar).The effects of surgical menopause on striatal medium spiny neurons. 2019 International Anatomical Sciences and Cell Biology,
14. Guo-Fang Tseng (2018, Mar).Silent mentor case study: extending the benefits of willed body program. 2018 International Anatomical Sciences and Cell Biology,
13. Li-Jin Chen, Ti-Yin Cheng, Yueh-Jan Wang, Guo-Fang Tseng (2018, Mar).The effects of infantile hydrocephalus on the striatum of the basal ganglia in a kaolin-induced rat model. 2018 International Anatomical Sciences and Cell Biology,
12. Li-Jin Chen, Hsiao-Wen Lai, Yueh-Jan Wang, Guo-Fang Tseng (2017, Mar). Intraventricular streptozotocin injection impaired cognition and reduced excitatory drives to the hippocampus in rats. 2017 International Anatomical Sciences and Cell Biology,
11. Li-Jin Chen, Ti-Yin Cheng, Yueh-Jan Wang, Guo-Fang Tseng (2017, Mar). The effects of experimental childhood hydrocephalus on the striatum in a rat model. 2017 International Anatomical Sciences and Cell Biology,
10. Li-Jin Chen, Ling-Chia Wang, Yueh-Jan Wang, Guo-Fang Tseng (2017, Mar). Focal cerebral compression results in irreversible contralateral cortical changes. 2017 International Anatomical Sciences and Cell Biology,
9. Guo-Fang Tseng, Li-Jin Chen, Yueh-Jan Wang (2016, Jul). Alteratios of the cerebral cortex and hippocampus in kaolin-induced hydrocephalic rats: a
stereological and intracellular dye injection study.
8. Li-Jin Chen, Ling-Chia Wang, Yueh-Jan Wang, Guo-Fang Tseng (2016, Mar).Unilateral cerebral compression affects contralateral cortex via downregulation of commissural projection profuseness and axonal transport machinery. 2015 International Anatomical Sciences and Cell Biology,
7. Li-Jin Chen, Ling-Chia Wang, Yueh-Jan Wang, Guo-Fang Tseng (2016, Mar).The Effects of Surgical Menopause Estrogen Receptor Expression and Dendritic
Spines in the Motor cortex. 2015 International Anatomical Sciences and Cell Biology,
6. Li-Jin Chen, Ling-Chia Wang, Yueh-Jan Wang, Guo-Fang Tseng (2016, Mar).Alteration of striatal glutamate and dopamine receptors accompanied motor
impairment in hydrocephalus. 2015 International Anatomical Sciences and Cell Biology,
5. Li-Jin Chen, Jeng-Rung Chen, Siang-Ying Huang, Yueh-Jan Wang, Guo-Fang Tseng (2014, Dec). The effect of chronic hydrocephalus and shunt treatment on
cortex and hippocampus in rats. 2014 International Anatomical Sciences and Cell Biology.
4. Li-Jin Chen, Ling-Chia Wang, Yeh-Yu Hsuan, Yueh-Jan Wang, Guo-Fang Tseng (2014, Dec). The effects of compression and decompression on the callosal
transmission of sensorimotor cortex. 2014 International Anatomical Sciences and Cell Biology.
3. Li-Jin Chen, Jeng-Rung Chen, Siang-Ying Huang, Yueh-Jan Wang, Guo-Fang Tseng (2014, Mar). Hydrocephalus and shunt treatment: effects on cortex and
hippocampus. 2014 Joint Annual Conference of Biomedical Science.
2. Li-Jin Chen, Jeng-Rung Chen, Siang-Ying Huang, Yueh-Jan Wang, Guo-Fang Tseng (2013, Mar). A stereological and cellular analysis on the effects of
hydrocephalus on cerebral cortex and hippocampus. 2013 Joint Annual Conference of Biomedical Science.
1. Li-Jin Chen, Ling-Chia Wang, Yueh-Jan Wang, Guo-Fang Tseng (2013, Mar). Compression reduces the transcortical projection of underlying cortex. 2013
Joint Annual Conference of Biomedical Science.